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‘ Although further studies underway are, their work suggests that disrupting Rb-Raf-1 interaction can prevent tumor cell proliferation, cell vascular growth , tumor growth, and the metastatic colonization of organs. ‘This process appears to become a successful avenue to fight metastatic disease,’ concluded Chellappan.. Chemical disruption to crucial interaction proven to limit metastasis in test mice Finding methods to counteract or disrupt the invasive nature of malignancy cells, called ‘metastasis,’ has been a long-term goal of cancers researchers. Now, researchers at Moffitt Cancer Middle in Tampa, Fla., have determined an interactive pathway that regulates metastases in a few cancers that may be vulnerable to chemical targeting in order to prevent tumor cell proliferation and tumor growth.