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Using a type of Benitec’s gene silencing technology in a rat model, the researchers silenced an integral gene associated with discomfort and achieved a substantial decrease in pain without unwanted effects. Their getting of significant efficacy without undesireable effects in the preclinical model gets the potential to considerably accelerate our attempts in getting a novel discomfort therapeutic to the clinic backed by our dominant patent placement in the underlying DNA-directed RNAi technology. *Reference: Wangyuan Zou, Zongbin Tune, Qulian Guo, Chang Liu, Zhong Zhang and Yanfeng Zhang.